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Takuji Okusaka Selected Research

Leukopenia

10/2020A randomized, double-blind, placebo-controlled, phase 3 study of tivantinib in Japanese patients with MET-high hepatocellular carcinoma.
6/2017A Phase I/II trial of continuous hepatic intra-arterial infusion of 5-fluorouracil, mitoxantrone and cisplatin for advanced hepatocellular carcinoma.
1/2013A multicenter phase II trial of S-1 with concurrent radiation therapy for locally advanced pancreatic cancer.
1/2009Do recurrent and metastatic pancreatic cancer patients have the same outcomes with gemcitabine treatment?
4/2008A phase II trial of transcatheter arterial infusion chemotherapy with an epirubicin-Lipiodol emulsion for advanced hepatocellular carcinoma refractory to transcatheter arterial embolization.
1/2007Hepatic arterial infusion chemotherapy with epirubicin in patients with advanced hepatocellular carcinoma and portal vein tumor thrombosis.
2/2005A phase II trial of continuous infusion of 5-fluorouracil, mitoxantrone, and cisplatin for metastatic hepatocellular carcinoma.

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Takuji Okusaka Research Topics

Disease

87Neoplasms (Cancer)
12/2022 - 01/2002
86Pancreatic Neoplasms (Pancreatic Cancer)
08/2022 - 01/2002
82Hepatocellular Carcinoma (Hepatoma)
09/2022 - 01/2002
38Biliary Tract Neoplasms (Biliary Tract Cancer)
06/2022 - 12/2002
16Adenocarcinoma
10/2020 - 01/2002
14Neutropenia
10/2020 - 04/2004
14Thrombocytopenia (Thrombopenia)
01/2018 - 02/2005
13Disease Progression
02/2021 - 03/2007
10Neuroendocrine Tumors (Neuroendocrine Tumor)
11/2021 - 02/2011
10Neoplasm Metastasis (Metastasis)
01/2016 - 04/2004
9Anorexia
01/2019 - 06/2006
8Hypertension (High Blood Pressure)
06/2020 - 03/2011
7Interstitial Lung Diseases (Interstitial Lung Disease)
07/2022 - 08/2010
7Ascites
03/2022 - 12/2007
7Cholangiocarcinoma
11/2020 - 11/2007
7Leukopenia
10/2020 - 02/2005
6Fibrosis (Cirrhosis)
06/2022 - 12/2010
6Carcinoma (Carcinomatosis)
11/2020 - 08/2005
6Exanthema (Rash)
01/2019 - 02/2011
5Stomach Neoplasms (Stomach Cancer)
06/2022 - 04/2014
5Gallbladder Neoplasms (Gallbladder Cancer)
08/2021 - 11/2007
5Liver Neoplasms (Liver Cancer)
10/2020 - 05/2012
5Anemia
10/2020 - 02/2011
5Liver Diseases (Liver Disease)
02/2020 - 01/2006
5Nausea
10/2018 - 06/2006
5Fatigue
01/2017 - 04/2008
5Infections
12/2016 - 09/2002
5Carcinogenesis
01/2016 - 05/2012
4Liver Cirrhosis (Hepatic Cirrhosis)
06/2022 - 02/2002
4Body Weight (Weight, Body)
01/2021 - 01/2005
4Neuroendocrine Carcinoma
01/2020 - 04/2010
3Pathologic Constriction (Stenosis)
12/2022 - 09/2020
3Hepatitis C
06/2022 - 01/2015
3Hemorrhage
07/2019 - 01/2004
3Stomatitis
01/2019 - 02/2011
3Hepatitis
01/2019 - 09/2012
3Diarrhea
12/2016 - 02/2011
3Drug-Related Side Effects and Adverse Reactions
10/2014 - 04/2005

Drug/Important Bio-Agent (IBA)

80GemcitabineFDA Link
01/2022 - 12/2002
32Cisplatin (Platino)FDA LinkGeneric
01/2022 - 01/2003
28Sorafenib (BAY 43-9006)FDA Link
01/2021 - 03/2010
22Pharmaceutical PreparationsIBA
07/2022 - 12/2002
19Fluorouracil (Carac)FDA LinkGeneric
10/2018 - 02/2002
16Biomarkers (Surrogate Marker)IBA
06/2022 - 11/2005
14Proteins (Proteins, Gene)FDA Link
03/2022 - 01/2011
12Aspartate Aminotransferases (Aspartate Transaminase)IBA
01/2019 - 11/2002
11RamucirumabIBA
06/2020 - 07/2015
8lenvatinibIBA
09/2022 - 03/2016
8Alanine Transaminase (SGPT)IBA
06/2017 - 02/2005
7folfirinoxIBA
08/2022 - 10/2014
7PlatinumIBA
10/2020 - 04/2004
7alpha-Fetoproteins (alpha-Fetoprotein)IBA
06/2020 - 01/2006
6Peptides (Polypeptides)IBA
01/2021 - 12/2009
6Erlotinib Hydrochloride (CP 358,774)FDA Link
01/2020 - 02/2011
6BilirubinIBA
10/2019 - 04/2004
6ProteomeIBA
02/2012 - 11/2005
6TegafurIBA
03/2011 - 01/2002
5Antineoplastic Agents (Antineoplastics)IBA
07/2022 - 05/2015
5Tyrosine Kinase InhibitorsIBA
01/2022 - 02/2011
5EverolimusFDA Link
11/2021 - 02/2011
5Protein Subunit VaccinesIBA
01/2021 - 12/2010
5Monoclonal AntibodiesIBA
01/2021 - 05/2014
5Epirubicin (Ellence)FDA LinkGeneric
02/2018 - 01/2003
5DNA (Deoxyribonucleic Acid)IBA
01/2017 - 01/2007
5EnzymesIBA
11/2015 - 09/2004
5UracilIBA
03/2011 - 01/2002
4Biological ProductsIBA
12/2020 - 09/2002
4Irinotecan (Camptosar)FDA LinkGeneric
10/2018 - 03/2007
4miriplatinIBA
02/2018 - 04/2004
4C-Reactive ProteinIBA
01/2016 - 01/2009
4Ethiodized Oil (Ethiodol)FDA Link
01/2014 - 01/2002
4S 1 (combination)IBA
01/2013 - 12/2010
3Serum AlbuminIBA
06/2022 - 11/2002
3GlypicansIBA
01/2021 - 04/2014
3Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA
01/2021 - 03/2011
3130-nm albumin-bound paclitaxelIBA
01/2021 - 10/2018
3Axitinib (AG 013736)IBA
01/2021 - 03/2011
3LigandsIBA
01/2021 - 01/2011
3Oxaliplatin (Eloxatin)FDA LinkGeneric
10/2020 - 01/2018
3Sunitinib (Sutent)FDA Link
06/2019 - 10/2013
3Fetal Proteins (Fetoprotein)IBA
01/2019 - 01/2015
3Immune Checkpoint InhibitorsIBA
01/2019 - 01/2018
3Streptozocin (Streptozotocin)FDA Link
10/2018 - 07/2015
3Mitoxantrone (Novantrone)FDA LinkGeneric
06/2017 - 02/2005
3Hepatitis B Surface Antigens (HBsAg)FDA Link
12/2016 - 09/2012
3Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
07/2015 - 03/2011
3Vascular Endothelial Growth Factor Receptor-2 (Vascular Endothelial Growth Factor Receptor 2)IBA
07/2015 - 02/2011
3(2E,4E,6E,10E)- 3,7,11,15- tetramethyl- 2,4,6,10,14- hexadecapentaenoic acidIBA
06/2015 - 06/2011
3Transaminases (Aminotransferases)IBA
02/2015 - 01/2005
3orantinib (SU6668)IBA
10/2014 - 02/2011

Therapy/Procedure

98Drug Therapy (Chemotherapy)
06/2022 - 01/2002
75Therapeutics
09/2022 - 12/2002
13Radiotherapy
01/2021 - 06/2003
11Combination Drug Therapy (Combination Chemotherapy)
01/2022 - 01/2005
9Chemoradiotherapy
02/2021 - 01/2004
8Stents
12/2022 - 10/2014
3Self Expandable Metallic Stents
12/2022 - 01/2021
3Choledochostomy
04/2022 - 01/2021
3Adjuvant Chemotherapy
10/2018 - 09/2012
3Immunotherapy
01/2018 - 12/2009